Complement Inhibitors for Geographic Atrophy

Treatment for Geographic Atrophy in Houston & San Antonio

Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD), a progressive eye condition that leads to the deterioration of the macula, the central part of the retina responsible for sharp, detailed vision. For those affected by GA, daily activities such as reading, driving, and recognizing faces can become increasingly challenging.

Fortunately, advancements in medical research have led to the development of complement inhibitor treatments designed to slow the progression of this debilitating condition.

What Are Complement Inhibitors?

Complement Inhibitors are a class of medication that inhibits complement proteins, which are key components of the complement system, a part of the body’s immune response. In geographic atrophy, the complement system becomes overactive, leading to inflammation and damage to the retinal cells. GA is characterized by the gradual and irreversible loss of retinal cells, leading to the formation of atrophic lesions in the macula. These lesions impair central vision, severely affecting the quality of life for those affected.

The two available complement inhibitors that are currently available are known as Syfovre and Izervay. Syfovre, also known by its generic name pegcetacoplan, and Izervay, known by its generic name avacincaptad pegol, are targeted therapies specifically approved for the treatment of GA secondary to AMD. Both medications bind and inhibit complement proteins C3 and C5, respectively, thus reducing inflammation and preventing further retinal cell death. This action helps to slow the progression of GA, preserving vision and potentially improving the patient's quality of life.

What to Expect with Complement Inhibitor Treatment

Complement inhibitors are administered via intravitreal injection directly into the eye. The injections are typically given by a retinal specialist in a clinical setting. The frequency of injections may vary based on the treatment regimen prescribed by the retina specialist.

Regular follow-up appointments with a retinal specialist are essential to monitor the treatment's progress and adjust the regimen as needed. During these visits, the specialist will perform thorough eye examinations and imaging to assess the effectiveness of the therapy and check for any adverse effects.

Visit Retina Consultants of Texas for Geographic Atrophy Treatment in Houston and San Antonio

Complement inhibitors such as Syfovre and Izervay represent a significant advancement in the treatment of geographic atrophy, offering new hope for patients with geographic atrophy. If you or a loved one is experiencing symptoms of geographic atrophy, contact Retina Consultants of Texas to discuss whether complement inhibitors may be an appropriate treatment option.